4 research outputs found
Mining and Analyzing the Italian Parliament: Party Structure and Evolution
The roll calls of the Italian Parliament in the XVI legislature are studied
by employing multidimensional scaling, hierarchical clustering, and network
analysis. In order to detect changes in voting behavior, the roll calls have
been divided in seven periods of six months each. All the methods employed
pointed out an increasing fragmentation of the political parties endorsing the
previous government that culminated in its downfall. By using the concept of
modularity at different resolution levels, we identify the community structure
of Parliament and its evolution in each of the considered time periods. The
analysis performed revealed as a valuable tool in detecting trends and drifts
of Parliamentarians. It showed its effectiveness at identifying political
parties and at providing insights on the temporal evolution of groups and their
cohesiveness, without having at disposal any knowledge about political
membership of Representatives.Comment: 27 pages, 14 figure
Defining Disease, Diagnosis, and Translational Medicine within a Homeostatic Perturbation Paradigm: The National Institutes of Health Undiagnosed Diseases Program Experience.
Traditionally, the use of genomic information for personalized medical decisions relies on prior discovery and validation of genotype-phenotype associations. This approach constrains care for patients presenting with undescribed problems. The National Institutes of Health (NIH) Undiagnosed Diseases Program (UDP) hypothesized that defining disease as maladaptation to an ecological niche allows delineation of a logical framework to diagnose and evaluate such patients. Herein, we present the philosophical bases, methodologies, and processes implemented by the NIH UDP. The NIH UDP incorporated use of the Human Phenotype Ontology, developed a genomic alignment strategy cognizant of parental genotypes, pursued agnostic biochemical analyses, implemented functional validation, and established virtual villages of global experts. This systematic approach provided a foundation for the diagnostic or non-diagnostic answers provided to patients and serves as a paradigm for scalable translational research. Front Med (Lausanne) 2017 May 26; 4:62